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Related Experiment Videos

Sarcopenia and noncoding RNAs: A comprehensive review.

Soudeh Ghafouri-Fard1, Arian Askari2, Bashdar Mahmud Hussen3

  • 1Department of Medical Genetics, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Journal of Cellular Physiology
|May 15, 2023
PubMed
Summary
This summary is machine-generated.

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Sarcopenia, an age-related muscle loss disease, involves noncoding RNAs. This review explores microRNAs and long noncoding RNAs roles in sarcopenia development and potential therapeutic targeting.

Area of Science:

  • Gerontology
  • Molecular Biology
  • Biochemistry

Background:

  • Sarcopenia is a significant health issue in older adults, characterized by muscle mass loss and frailty.
  • The precise molecular underpinnings of sarcopenia remain incompletely understood.
  • Noncoding RNAs have emerged as critical regulators in various diseases, including age-related conditions.

Purpose of the Study:

  • To review the current understanding of noncoding RNAs in sarcopenia pathogenesis.
  • To elucidate the roles of microRNAs and long noncoding RNAs in the development and progression of sarcopenia.
  • To discuss the therapeutic potential of targeting noncoding RNAs for sarcopenia.

Main Methods:

  • Literature review of studies investigating noncoding RNAs and sarcopenia.
Keywords:
lncRNAmiRNAsmuscle atrophynoncoding RNAsarcopenia

Related Experiment Videos

  • Analysis of research on microRNA and long noncoding RNA functions in muscle aging.
  • Synthesis of data on the regulatory roles of noncoding RNAs in sarcopenia.

    • Main Results:

    • Noncoding RNAs, including microRNAs and long noncoding RNAs, are implicated in the molecular pathways of sarcopenia.
    • These molecules regulate key processes involved in muscle atrophy and dysfunction.
    • Evidence suggests noncoding RNAs are crucial in the development and progression of age-related muscle loss.

    Conclusions:

    • Noncoding RNAs represent a promising area for understanding sarcopenia.
    • Targeting specific microRNAs and long noncoding RNAs may offer novel therapeutic strategies for sarcopenia.
    • Further research into noncoding RNA mechanisms is warranted for effective interventions.