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Updated: Jul 30, 2025

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Published on: June 10, 2021
Atom-Economical Syntheses of Dihydropyrroles Using Flavin-Iodine-Catalyzed Aerobic Multistep and Multicomponent
Aki Takeda1, Marina Oka1, Hiroki Iida1
1Department of Chemistry, Graduate School of Natural Science and Technology, Shimane University, 1060 Nishikawatsu, Matsue 690-8504, Japan.
Abstract:
Herein, we report facile, atom-economical syntheses of multisubstituted 2,3-dihydropyrroles using flavin-iodine-catalyzed aerobic oxidative multistep transformations of chalcones with β-enamine ketones or 1,3-dicarbonyl compounds and amines. Exploiting coupled flavin-iodine catalysis, the multistep reaction, including C-C and C-N bond formation, is promoted only by the consumption of O2 (1 atm), thus allowing aerobic oxidative synthesis that generates green H2O as the only waste.
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