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Updated: Jul 30, 2025

Continuous Fluorescence-Based Endonuclease-Coupled DNA Methylation Assay to Screen for DNA Methyltransferase Inhibitors
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Mechanism-based Suppression of Cancer by Targeting DNA-Replicating Enzymes

Preeti Arya1, Hitesh Malhotra1, Benu Chaudhary1

  • 1Guru Gobind Singh College of Pharmacy, Yamunanagar, Haryana, India.

Current Protein & Peptide Science
|May 15, 2023
PubMed

Insights

Cancer cells exhibit defective DNA repair, unlike normal cells. Targeting DNA replication with drugs like PARP inhibitors offers a promising, tumor-specific cancer therapy approach.

Area of Science:

  • Molecular Biology
  • Genetics
  • Oncology

Background:

  • Cellular integrity relies on DNA repair mechanisms, which are often compromised in cancer cells.
  • Cancer cells display altered signaling pathways and defective checkpoints, leading to errors in DNA repair and synthesis.
  • Targeting the DNA damage response (DDR) in cancer presents a significant therapeutic opportunity.

Conclusions:

  • Targeting DNA replication and repair pathways is a viable strategy for cancer treatment.
  • PARP and PARG inhibitors show considerable promise in preclinical and clinical settings.
  • Future cancer therapy will likely focus on precise, targeted interventions in DNA replication and repair.
Keywords:
CancerDNA damage responsePARPcancer cells.thymidylate synthasetopoisomerase

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