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Rapid Generation of Amyloid from Native Proteins In vitro
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The amyloid cascade hypothesis: an updated critical review

Kasper P Kepp1, Nikolaos K Robakis2, Poul F Høilund-Carlsen3,4

  • 1Section of Biophysical and Biomedicinal chemistry, DTU Chemistry, Technical University of Denmark, 2800 Kongens Lyngby, Denmark.

Brain : a Journal of Neurology
|May 15, 2023
PubMed
Summary

Recent Alzheimer's disease antibody trials targeting amyloid-beta (Aβ) show uncertain clinical effects, questioning the amyloid cascade hypothesis. New evidence suggests Aβ plays a minor role, supporting multifactorial disease models for effective Alzheimer's treatments.

Keywords:
Alzheimer’s diseaseaducanumabamyloid cascade hypothesislecanemabβ-amyloid

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