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Using a Murine Model of Psychosocial Stress in Pregnancy as a Translationally Relevant Paradigm for Psychiatric Disorders in Mothers and Infants
Published on: June 13, 2021
Within-person pathways among maternal depressive symptoms and offspring internalizing problems from early childhood
Simone Chad-Friedman1, Emma Chad-Friedman2, Edward Lemay2
1Catholic University of America, USA.
Insights
Early childhood internalizing symptoms in children predict later internalizing problems in both the child and mother. Early identification and prevention of these symptoms are crucial for mitigating negative effects on child and parent mental health.
Area of Science:
- Developmental Psychology
- Child Psychiatry
- Maternal Mental Health
Background:
- Examined reciprocal associations between maternal depressive symptoms and offspring internalizing symptoms.
- Focused on developmental pathways from early childhood to adolescence.
Purpose of the Study:
- Investigate within-person associations among maternal and child depressive, anxiety, and irritability symptoms.
- Utilize a random intercept cross-lagged panel model (RI-CLPM) for analysis.
Main Methods:
- Analyzed data from 609 mother-child dyads in the Stony Brook Temperament Study.
- Assessed child and maternal internalizing symptoms every 3 years (ages 3-15) via maternal report (CBCL, Diagnostic Inventory for Depression).
Main Results:
- Positive between-person associations found between maternal depressive symptoms and child internalizing symptoms.
- Early child anxiety (age 3) predicted later child anxiety/depression (age 15) through middle childhood.
- Early child irritability (age 3) predicted later maternal depressive symptoms (age 15) via middle childhood irritability.
Conclusions:
- Identified novel within-person developmental pathways linking early childhood internalizing problems to later issues in children and mothers.
- Emphasized the need for early detection and prevention of childhood internalizing symptoms to improve child and maternal mental health outcomes.
Introduction:
The report examined reciprocal within-person associations among maternal depressive symptoms and offspring depressive, anxiety and irritability symptoms from early childhood to adolescence using a random intercept cross-lagged panel model (RI-CLPM).
Method:
Participants were 609 mother-child dyads participating in the Stony Brook Temperament Study. Child and maternal internalizing symptoms were assessed every 3 years from ages 3 to 15 using maternal report on the Child Behavior Checklist (CBCL) and Diagnostic Inventory for Depression, respectively.
Results:
At the between-person level, maternal depressive symptoms, and child depressive, anxiety, and irritability symptoms were all positively associated with one another. At the within-person level, greater within-person child anxiety symptoms at age 3 predicted both greater child anxiety and depressive symptoms at age 15 via greater child anxiety from ages 6 to 12, and greater within-person child irritability at age 3 predicted greater maternal depressive symptoms at age 15 via greater child irritability from ages 6 to 12.
Conclusions:
Findings reveal novel within-person developmental pathways from early childhood internalizing problems to later internalizing problems in both the child and mother. Intervention and prevention efforts should thus focus on early identification and prevention of childhood internalizing symptoms to reduce negative effects on both child and parent symptoms.
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