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Updated: Jul 30, 2025

Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT
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Study of In Vivo Glucose Metabolism in High-fat Diet-fed Mice Using Oral Glucose Tolerance Test OGTT and Insulin Tolerance Test ITT

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Sodium-glucose cotransporter 2 inhibitors and the risk of venous thromboembolism: A population-based cohort study

Stephanie Aloe1,2, Christopher Filliter2, Shahrzad Salmasi2,3

  • 1Department of Endocrinology & Metabolism, McGill University, Montreal, Quebec, Canada.

British Journal of Clinical Pharmacology
|May 15, 2023
PubMed
Abstract

Insights

Sodium-glucose cotransporter 2 inhibitors (SGLT2Is) do not increase the risk of venous thromboembolism (VTE) in patients with type 2 diabetes. This study found no significant association between SGLT2I use and VTE risk compared to DPP-4 inhibitors.

Area of Science:

  • Cardiology
  • Endocrinology
  • Pharmacology

Background:

  • Sodium-glucose cotransporter 2 inhibitors (SGLT2Is) offer cardiovascular benefits, primarily through arterial effects.
  • The impact of SGLT2Is on venous vessels and the risk of venous thromboembolism (VTE) remains incompletely understood.
  • Existing meta-analyses suggest no significant VTE risk alteration, but observational data are limited.

Conclusions:

  • SGLT2 inhibitors are not associated with an increased risk of VTE compared to DPP-4 inhibitors in type 2 diabetes patients.
  • The observed trend towards a decreased VTE risk with SGLT2Is warrants further investigation.
  • These findings offer reassurance regarding the safety of SGLT2Is concerning VTE risk.
Keywords:
clinical pharmacologyclinical pharmacology, medication safetyclinical pharmacology, prescribingdrug information

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