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[Sepsis and blood coagulation].

G Müller-Berghaus

    Behring Institute Mitteilungen
    |February 1, 1986
    PubMed
    Summary

    Septicemia often causes disseminated intravascular coagulation (DIC), a bleeding disorder. DIC involves coagulation changes, microclot formation, and bleeding due to toxic agents and reduced fibrinolysis.

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    Area of Science:

    • Hematology
    • Pathophysiology
    • Microbiology

    Context:

    • Septicemia frequently alters coagulation systems, leading to microclot formation.
    • Hemorrhagic diathesis and microthrombosis in septicemia are explained by disseminated intravascular coagulation (DIC).

    Purpose:

    • To explain the mechanisms of disseminated intravascular coagulation (DIC) in septicemia.
    • To elucidate the role of endotoxin, tissue factor, and fibrinolysis in DIC pathogenesis.

    Summary:

    • Septicemia triggers DIC through various pathways, notably endotoxin-mediated activation of coagulation via tissue factor synthesis.
    • Microthrombi form from soluble fibrin precipitation under reduced fibrinolysis.
    • Thrombocytopenia, thrombocytopathy, and endothelial damage contribute to the bleeding diathesis in DIC.

    Impact:

    • Understanding DIC mechanisms in septicemia aids in developing targeted therapeutic strategies.
    • This knowledge is crucial for managing bleeding complications and improving patient outcomes in sepsis.

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