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The emergence of primary negative symptoms: relevance of timing?
Eric Yu Hai Chen1,2, Stephanie Ming Yin Wong1, Christy Lai Ming Hui1
1Department of Psychiatry, School of Clinical Medicine, LKS Faculty of Medicine, The University of Hong Kong, Hong Kong.
Abstract:
Negative symptoms are an important symptom dimension in schizophrenia that are often least responsive to antipsychotic medications. We revisit the current practice of identifying 'primary' negative symptoms and suggest that its concept would benefit from a further elaboration of their timing of emergence in relation to the dynamic neurobiological changes to enhance their utility in clinical decision-making and research.
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