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Lupus enteritis: A 10-year experience in a single Latin American center
Marcela Muñoz-Urbano1, Julián Sanchez-Bautista1, Andrés Ramírez1
1Division of Rheumatology, Department of Internal Medicine, School of Medicine, Universidad de Antioquia, Hospital San Vicente Fundación, Medellín, Colombia.
Lupus
|May 15, 2023
Summary
Lupus enteritis (LE) in systemic lupus erythematosus (SLE) patients often presents early in the disease course, frequently with lupus nephritis. Higher SLE disease activity scores independently predict LE occurrence.
Area of Science:
- Rheumatology
- Gastroenterology
- Internal Medicine
Background:
- Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse clinical manifestations.
- Lupus enteritis (LE), a gastrointestinal manifestation of SLE, requires understanding its clinical characteristics and associations.
Purpose of the Study:
- To compare clinical and laboratory features of SLE patients with and without lupus enteritis (LE).
- To identify factors associated with the occurrence of LE in hospitalized SLE patients.
Main Methods:
- Retrospective, case-control study of hospitalized SLE patients (January 2012 - December 2021).
- Sixteen LE patients (cases) were matched 1:3 with 48 non-LE patients (controls).
- Univariable and multivariable logistic regression analyses were employed.
Main Results:
- LE occurred in 0.65% of hospitalized SLE patients.
- LE patients exhibited shorter disease duration, longer hospital stays, and higher SLEDAI-2K scores.
- Concomitant lupus nephritis was present in 93.8% of LE patients.
- Higher SLEDAI-2K scores were independently associated with LE occurrence (OR 1.10, p=0.015).
Conclusions:
- In Mestizo patients, LE often occurs early in SLE, sometimes as a presenting manifestation, frequently with lupus nephritis.
- Elevated disease activity at diagnosis is an independent predictor of LE.
- Recurrences of LE are associated with severe bowel wall thickening.
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