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Published on: November 8, 2015
Oral Tacrolimus in Steroid Refractory and Dependent Pediatric Ulcerative Colitis-A Systematic Review and
Rishi Bolia1, Akhil Goel2, Pooja Semwal3
1From the Department of Gastroenterology, Hepatology and Liver Transplant, Queensland Children's Hospital, Brisbane, Australia.
Oral tacrolimus shows high initial effectiveness in children with ulcerative colitis (UC) who have not used biologics. This treatment offers a 64% colectomy-free survival at one year, serving as a crucial bridge therapy.
Area of Science:
- Pediatric Gastroenterology
- Immunosuppressive Therapy
Background:
- Limited treatment options exist for pediatric patients with steroid-refractory or steroid-dependent ulcerative colitis (UC).
- Observational studies suggest oral tacrolimus may be effective in this population.
Conclusions:
- Oral tacrolimus demonstrates a high initial response rate in biologic-naïve pediatric UC patients.
- It serves as an effective bridge therapy, achieving a 64% one-year colectomy-free survival.
- Further research may explore its long-term efficacy and safety profile.
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