Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

StyleGAN-based synthetic image augmentation for multi-class otoscopy image classification.

Scientific reports·2026
Same author

Morphology-Aware Prognostic Model for Five-Year Survival Prediction in Colorectal Cancer from H&E Whole-Slide Images: A Study Using Multi-Center Clinical Trial Cohort.

Cancers·2026
Same author

SHIELD: An AI Framework for Skeletal Health Intelligence and Early Lesion Detection to Improve Orthopedic Referrals.

Journal of medical systems·2026
Same author

Decoding Clinician Authorial Style: A Style-Informed Pipeline for Clinical Document Summary Generation with Large Language Models.

Research square·2026
Same author

In-Situ ssDNA Isolation from dsDNA Sources as a Streamlined Pathway to DNA Origami Assembly and Testing.

bioRxiv : the preprint server for biology·2026
Same author

Tunable DNA Origami Nanosensors for Detection of Multiscale Spatial Ion Concentration Gradients.

ACS sensors·2026
Same journal

Unraveling the synergy of core doping and the motif shell in atomically precise PtAg nanoclusters for CF<sub>3</sub>-ketone alkynylation.

Nanoscale·2026
Same journal

A dual-functional heavy-metal-free quantum dot/TiO<sub>2</sub> hybrid system for simultaneous pollutant degradation and green hydrogen production.

Nanoscale·2026
Same journal

Rational design of spherical NiCoB@rGO nanocomposites for efficient electrochemical energy storage.

Nanoscale·2026
Same journal

Ligand-controlled engineering of Cu-H active sites on Cu<sub>25</sub> hydride nanoclusters for efficient CO<sub>2</sub> electroreduction.

Nanoscale·2026
Same journal

Isostructural Co/Ni-containing banana-shaped polyoxometalates for visible-light-driven hydrogen production.

Nanoscale·2026
Same journal

Exploring gefitinib to enhance endocytosis of antibodies and nucleic acid aptamers targeting EGFR in glioblastoma.

Nanoscale·2026
See all related articles

Related Experiment Video

Updated: Jul 30, 2025

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
08:30

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

9.1K

DNA-caged nanoparticles via electrostatic self-assembly.

Elizabeth Jergens1, Silvio de Araujo Fernandes-Junior1,2,3, Yixiao Cui4

  • 1William G. Lowrie Department of Chemical and Biomolecular Engineering, The Ohio State University, Columbus, OH, USA. winter.63@osu.edu.

Nanoscale
|May 15, 2023
PubMed
Summary
This summary is machine-generated.

We developed a novel electrostatic DNA caging method for modifying nanoparticles. This technique offers controlled DNA presentation on various nanoparticles for applications in nanomedicine and materials science.

More Related Videos

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

11.2K
Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.3K

Related Experiment Videos

Last Updated: Jul 30, 2025

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures
08:30

Gene-therapy Inspired Polycation Coating for Protection of DNA Origami Nanostructures

Published on: January 19, 2019

9.1K
Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time
14:36

Combining QD-FRET and Microfluidics to Monitor DNA Nanocomplex Self-Assembly in Real-Time

Published on: August 26, 2009

11.2K
Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures
08:15

Self-Assembly of Gamma-Modified Peptide Nucleic Acids into Complex Nanostructures in Organic Solvent Mixtures

Published on: June 26, 2020

4.3K

Area of Science:

  • Nanomaterials
  • DNA nanotechnology
  • Surface chemistry

Background:

  • DNA-modified nanoparticles are vital for nanomedicine and DNA-based material self-assembly.
  • Current DNA conjugation methods are inefficient and lack precise control over DNA presentation.

Purpose of the Study:

  • To introduce a new, controllable method for modifying nanoparticle surfaces with DNA using electrostatic attraction.
  • To demonstrate the versatility of this approach across different nanoparticle types and sizes.

Main Methods:

  • Utilized electrostatic attraction between negatively charged DNA tiles and positively charged nanoparticles.
  • Employed transmission electron microscopy (TEM), zeta potential analysis, and fluorescence experiments to confirm DNA cage formation.
  • Tested DNA handle functionality in solution, at interfaces, and within fixed cells.

Main Results:

  • Successfully formed DNA cages on various nanoparticles (polymeric micelles, polystyrene beads, gold nanoparticles, superparamagnetic iron oxide nanoparticles) ranging from 5-20 nm.
  • Confirmed DNA cage formation and demonstrated the programmability of DNA presentation.
  • Verified the functionality of DNA 'handle' sequences for reversible attachment and self-assembly.

Conclusions:

  • The electrostatic DNA caging approach provides a versatile and controllable pathway for nanoparticle modification with DNA.
  • This method enhances the utility of DNA-nanoparticle conjugates for diverse applications in biosensing, DNA microarrays, and erasable immunocytochemistry.
  • This work opens new avenues for advanced applications in nanomedicine and materials science.