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Genetic Predisposition to Periodontitis and Risk of Migraine: A Two-Sample Mendelian Randomization Study

Zhen-Ni Zhao1, Zi-Qian Zhang1, Qian-Qian Wang1,2

  • 1Shanxi Province Key Laboratory of Oral Diseases Prevention and New Materials, Shanxi Medical University School and Hospital of Stomatology, Taiyuan, 030001, China.

Neurology and Therapy
|May 15, 2023
PubMed
Abstract

Insights

This study found no causal link between periodontitis (PD) and migraine. Mendelian randomization analysis confirmed no evidence supports a bi-directional relationship between these conditions.

Area of Science:

  • Genetics
  • Epidemiology
  • Oral Health

Background:

  • Observational studies suggest a link between periodontitis (PD) and migraine, but causality remains unproven.
  • Previous research findings are inconclusive regarding the association between PD and migraine.

Purpose of the Study:

  • To investigate the bi-directional causal relationship between periodontitis and migraine using Mendelian randomization.
  • To clarify the potential causal link between PD and migraine.

Main Methods:

  • A two-sample Mendelian randomization (MR) study utilizing genome-wide association data from European populations.
  • Employed Inverse Variance-Weighted (IVW) method and sensitivity analyses with seven single nucleotide polymorphisms (SNPs) for PD.
  • Analyzed large datasets: 17,353 PD cases and 28,210 controls; 1072 migraine cases and 360,122 controls.

Main Results:

  • No significant causal relationship was found between periodontitis and migraine (OR=1.000, p=0.65).
  • No evidence supported a causal relationship between migraine and periodontitis (OR=0.07, p=0.77).
  • Sensitivity analyses indicated no significant heterogeneity or pleiotropic effects from the genetic variants used.

Conclusions:

  • The Mendelian randomization study found no evidence of a causal relationship between periodontitis and migraine in either direction.
  • The findings suggest that the observed association in previous studies may not be causal.
Keywords:
Causal relationshipGenetic correlationMendelian randomizationMigrainePeriodontitis

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