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Related Concept Videos

Formation of the Platelet Plug01:22

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The platelet phase, the second stage of hemostasis, commences around 15-20 seconds after an injury. It follows and overlaps with the vascular phase, during which blood vessels constrict to minimize blood loss.
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The cell fragments known as platelets are disc-shaped, with an average diameter of about 3 μm and a thickness of roughly 1 μm. They play a crucial role in the body's vascular clotting system, which also involves plasma proteins, blood cells, and blood vessel tissues.
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Related Experiment Video

Updated: Jul 30, 2025

Microfluidics in Assessing Platelet Function
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Microfluidics in Assessing Platelet Function

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Association between minimal decrease in platelet counts and outcomes in septic patients: a retrospective

Xing Liu1, Wanhong Yin2, Yi Li1

  • 1Department of Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, Sichuan, China.

BMJ Open
|May 15, 2023
PubMed
Summary
This summary is machine-generated.

A decrease in platelet count percentage by 10% in sepsis patients after treatment is linked to lower 30-day mortality. This finding suggests platelet count changes can indicate sepsis treatment effectiveness.

Keywords:
adult intensive & critical careinfectious diseasesintensive & critical care

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Area of Science:

  • Critical care medicine
  • Hematology
  • Sepsis research

Background:

  • Platelets are implicated in sepsis inflammation, but their role as a treatment indicator is unclear.
  • Understanding platelet dynamics is crucial for optimizing sepsis therapy.

Purpose of the Study:

  • To investigate the association between time-dependent changes in platelet counts and mortality rates in sepsis patients.
  • To determine if platelet count changes can serve as an indicator of sepsis treatment efficacy.

Main Methods:

  • Retrospective cohort study utilizing the Medical Information Mart for Intensive Care (MIMIC-IV) database.
  • Analysis of 7981 patients admitted to Beth Israel Deaconess Medical Center (BIDMC) between 2008-2019, diagnosed with sepsis.
  • Evaluation of 30-day mortality, ICU length of stay, and hospitalization duration based on platelet count percentage changes.

Main Results:

  • A decrease of ≤10% in platelet count proportion was associated with significantly lower 30-day mortality (14.1% vs 23.5%).
  • Multivariable analysis confirmed that a ≤10% decrease in platelet count by day 4 post-ICU admission correlated with reduced 30-day non-survival.
  • Patients with ≤10% platelet count reduction experienced shorter ICU stays (6.8 vs 7.5 days).

Conclusions:

  • A ≤10% decrease in platelet count percentage after sepsis treatment is an independent predictor of decreased 30-day mortality.
  • Changes in platelet count proportion post-treatment may serve as a valuable indicator for assessing sepsis therapeutic effects.