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Updated: Jul 30, 2025

Semiconductor Sequencing for Preimplantation Genetic Testing for Aneuploidy
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Does PGT-A affect cumulative live birth rate?

Serin Seckin1, Eric J Forman

  • 1Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Columbia University Fertility Center, Columbia University Irving Medical Center, New York, New York, USA.

Current Opinion in Obstetrics & Gynecology
|May 15, 2023
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Summary
This summary is machine-generated.

Preimplantation genetic testing for aneuploidy screening (PGT-A) aims to improve live birth rates per transfer, not overall cumulative rates. While concerns exist about PGT-A potentially decreasing cumulative live birth rates, its role as a selection tool remains important.

Area of Science:

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  • Reproductive medicine
  • Genetics
  • In vitro fertilization

Background:

  • Preimplantation genetic testing for aneuploidy screening (PGT-A) has seen increased utilization.
  • Concerns exist regarding PGT-A's impact on cumulative live birth rates (CLBR), particularly in younger patients.

Conclusions:

  • PGT-A's primary goal is not to increase CLBR but to optimize outcomes per transfer.
  • The impact of PGT-A on CLBR requires careful consideration alongside its benefits as a selection tool.