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Nanozymes towards Personalized Diagnostics: A Recent Progress in Biosensing.

Chitra Padmakumari Kurup1, Minhaz Uddin Ahmed1

  • 1Biosensors and Nanobiotechnology Laboratory, Integrated Science Building, Faculty of Science, Universiti Brunei Darussalam, Jalan Tungku Link, Gadong BE1410, Brunei.

Biosensors
|May 15, 2023
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Summary

Nanozymes, enzyme mimics, offer enhanced point-of-care biosensors with improved stability and miniaturization. Future developments promise revolutionary advancements in sensitive, low-cost diagnostics.

Keywords:
SERSSODcatalasecolorimetricelectrochemicalfluorescencenanozymeoxidaseperoxidasepoint of care

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Analytical Chemistry

Background:

  • Nanozymes are enzyme-mimicking nanomaterials offering superior stability and tunability compared to traditional enzymes.
  • Their application in biosensing enables improved performance and miniaturization of diagnostic devices.
  • Diverse nanomaterials like metals, metal oxides, and MOFs are utilized for nanozyme development.

Purpose of the Study:

  • To review recent advancements in nanozymes for point-of-care biosensor development.
  • To highlight the advantages and challenges of using nanozymes in biosensing.
  • To discuss the future potential of nanozyme-based diagnostics.

Main Methods:

  • Review of literature on nanozyme synthesis and characterization.
  • Analysis of various sensing strategies (colorimetric, fluorescent, electrochemical, SERS) employing nanozymes.
  • Evaluation of nanozyme properties like stability, robustness, and surface tunability.

Main Results:

  • Nanozymes provide a robust and tunable platform for biosensor development.
  • Various nanomaterials have been successfully engineered as nanozymes for diverse sensing applications.
  • Nanozyme-based biosensors demonstrate potential for high sensitivity and miniaturization.

Conclusions:

  • Nanozymes present a promising alternative to enzymes in biosensing, offering enhanced performance.
  • Challenges in stability and specificity need to be addressed for broader clinical application.
  • Nanozyme integration into point-of-care diagnostics could revolutionize healthcare with accurate, cost-effective tools.