Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Complement activation in rheumatoid arthritis evaluated by C3dg and the terminal complement complex.

T E Mollnes, T Lea, O J Mellbye

    Arthritis and Rheumatism
    |June 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Zinc depletion regulates the processing and secretion of IL-1β.

    Cell death & disease·2014
    Same author

    Professor emeritus Jacob B. Natvig, one of the founders of Scandinavian journal of immunology, turns 75.

    Scandinavian journal of immunology·2009
    Same author

    Innate immune responses to danger signals in systemic inflammatory response syndrome and sepsis.

    Scandinavian journal of immunology·2009
    Same author

    IgA rheumatoid factor in primary Sjogren's syndrome.

    Scandinavian journal of rheumatology·2008
    Same author

    Cytokines, bone turnover markers and weight change in candidates for lung transplantation.

    Pulmonary pharmacology & therapeutics·2007
    Same author

    Female genital tuberculosis in Ethiopia.

    Ethiopian medical journal·2006

    Complement activation is significant in rheumatoid arthritis synovial fluid and sometimes in plasma. Examining both fluid and plasma is crucial for a full understanding of complement activation in rheumatoid arthritis.

    Area of Science:

    • Immunology
    • Rheumatology

    Background:

    • Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint inflammation.
    • The complement system, a key part of innate immunity, plays a role in RA pathogenesis.

    Purpose of the Study:

    • To evaluate complement system activation in both synovial fluid and plasma of RA patients.
    • To determine the relationship between local (synovial) and systemic (plasma) complement activation in RA.

    Main Methods:

    • Assessed complement activation using C3dg (initial activation) and terminal complement complex (terminal activation) as biomarkers.
    • Analyzed plasma and synovial fluid samples from patients with rheumatoid arthritis.

    Main Results:

    • Significant complement cascade activation was observed in most synovial fluid samples.

    Related Experiment Videos

  • Complement activation was also detected in one-third of plasma samples.
  • No correlation was found between complement activation levels in synovial fluid and plasma.

    • Conclusions:

    • Complement activation occurs extensively within the joints of RA patients.
    • Systemic complement activation in plasma is not always correlated with local joint activation.
    • Evaluating both synovial fluid and plasma is essential for a comprehensive assessment of complement activation in rheumatoid arthritis.