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Comment on Duarte et al. Systematic Review and Network Meta-analysis of Neurostimulation for Painful Diabetic

Ashwini D Sharan1,2, John A Hatheway3, Melissa Murphy4

  • 11Medtronic, Minneapolis, MN.

Diabetes Care
|May 15, 2023
PubMed
Abstract

No abstract available in PubMed .

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Diabetic Neuropathy01:22

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DefinitionDiabetic neuropathy is nerve damage caused by long-standing diabetes mellitus. It results directly from prolonged high blood sugar levels.PathophysiologyThe pathophysiology of diabetic neuropathy involves both metabolic and vascular disturbances triggered by chronic hyperglycemia.Metabolic injury: Elevated glucose levels activate the polyol pathway within nerve cells, leading to the accumulation of sorbitol and fructose. This increases oxidative stress, disrupts normal nerve...

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