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Related Experiment Video

Updated: Jul 30, 2025

Performing Data Mining And Integrative Analysis Of Biomarker in Breast Cancer Using Multiple Publicly Accessible Databases

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Published on: May 17, 2019

BCL11A Expression in Breast Cancer.

Ewa Kątnik¹, Agnieszka Gomułkiewicz¹, Aleksandra Piotrowska¹

¹Division of Histology and Embryology, Department of Human Morphology and Embryology, Wroclaw Medical University, 50-368 Wroclaw, Poland.

Current Issues in Molecular Biology

|May 15, 2023

Summary

B-cell leukemia/lymphoma 11A (BCL11A) is upregulated in breast cancer (BC) compared to normal tissue. Its expression decreases with higher tumor grade and smaller tumor size, suggesting a role in BC development.

Keywords:

BC BCL11A TN breast cancer cancer cell triple-negative breast cancer

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Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Clinicopathological Analysis of miRNA Expression in Breast Cancer Tissues by Using miRNA In Situ Hybridization

Published on: June 7, 2016

Area of Science:

Oncology
Molecular Biology
Genetics

Background:

B-cell leukemia/lymphoma 11A (BCL11A) is a transcription factor regulating cell division and apoptosis.
Elevated BCL11A expression is linked to poorer prognosis in various cancers.

Purpose of the Study:

To investigate BCL11A expression patterns in breast cancer (BC) and mastopathy.
To correlate BCL11A expression with clinicopathological data in BC.

Main Methods:

Immunohistochemistry (IHC) for BCL11A protein in 200 BC and 13 mastopathy samples.
Real-time PCR for BCL11A mRNA in 22 BC and 6 mastopathy samples.
Analysis of BCL11A in BC cell lines at protein and mRNA levels.

Main Results:

BCL11A expression was higher in BC than in mastopathy.
BCL11A levels decreased with increasing histological grade and primary tumor size in BC.
Lower BCL11A expression was observed in estrogen/progesterone receptor-negative and triple-negative BC.

Conclusions:

BCL11A expression is altered in breast cancer.
BCL11A may play a role in breast cancer development and progression.
BCL11A's correlation with clinicopathological features warrants further investigation.