Interactions of brotizolam and diazepam with some psychotropic drugs on motor performance in mice

The interaction of brotizolam (2-bromo-4-(2-chlorophenyl)-9-methyl-6H-thieno [3,2-f]-1,2,4-triazolo[4,3-a]-1,4-diazepine, We 941, Lendormin) and diazepam with ethanol, phenobarbital, haloperidol and desipramine was investigated in a motor performance test (rotarod) in mice. Brotizolam and diazepam were tested at dose levels which partially impaired the motor performance. In combination with ethanol and phenobarbital only the anticipated additive effect was observed. Brotizolam and diazepam partially overcame the cataleptic effect of haloperidol. A combined treatment with brotizolam and desipramine did not alter the effect obtained with brotizolam alone. In a second experiment the loss of righting reflexes induced by ethanol and hexobarbital was prolonged by brotizolam and diazepam depending on the dose. From this it is concluded that in combination with ethanol brotizolam and diazepam may be effective at antiemotional and anticonvulsant doses. In combination with hexobarbital brotizolam is expected to have a greater "therapeutic range".