Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Drugs for Treatment of Constipation-Predominant IBS01:21

Drugs for Treatment of Constipation-Predominant IBS

242
Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
242
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

227
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
227
Inflammatory Bowel Disease V: Surgical Management01:21

Inflammatory Bowel Disease V: Surgical Management

178
Surgical interventions for inflammatory bowel disease (IBD), which includes ulcerative colitis and Crohn's disease, are essential in managing symptoms and addressing complications. The selection of surgical procedures is contingent upon the specific conditions and complications that stem from these illnesses.
Here are some common surgical interventions for IBD:
178
Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

256
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
256
Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

495
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
495
Drugs Affecting GI Tract Motility: Other Laxatives01:20

Drugs Affecting GI Tract Motility: Other Laxatives

298
Laxatives are primarily used to alleviate constipation, a common gastrointestinal disorder characterized by infrequent bowel movements and difficulty passing stools. They work by various mechanisms to increase the volume or frequency of bowel movements. The primary modes of action of laxatives include increasing stool bulk, softening the stool, stimulating intestinal motility, and osmotically drawing water into the intestines.
Osmotic or saline laxatives, like magnesium hydroxide or milk of...
298

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

From Adaptive to Maladaptive Eating Behavior in Disorders of Gut-Brain Interaction.

Neurogastroenterology and motility·2026
Same author

Prevalence and Impact of Disorders of Gut-Brain Interaction in France: Results From the Rome Foundation Global Epidemiology Study.

Neurogastroenterology and motility·2026
Same author

Esophageal Clearance Assessed by High-Resolution Impedance Manometry in Achalasia: A Prospective Study With 1-Year Follow-up.

The American journal of gastroenterology·2026
Same author

Laryngopharyngeal Symptoms and Laryngopharyngeal Reflux Disease: Diagnostic Testing and Clinical Approach Based on the San Diego Consensus.

Neurogastroenterology and motility·2026
Same author

Artificial Intelligence Chatbots for Dysphagia Patient Education: A Multi-Center International Expert Evaluation.

Neurogastroenterology and motility·2026
Same author

Insomnia, A Comorbidity to Take Into Account in the Global Management of Patients With Irritable Bowel Syndrome?

Neurogastroenterology and motility·2026

Related Experiment Video

Updated: Jul 30, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

483

Interferential therapy for chronic constipation in adults: The CON-COUR randomizedcontrolled trial.

Veronique Vitton1, François Mion2, Anne-Marie Leroi3,4,5

  • 1Gastroenterology Unit, Assistance Publique-Hôpitaux de Marseille, Aix-Marseille Université, Marseille, France.

United European Gastroenterology Journal
|May 15, 2023
PubMed
Summary

Transabdominal electrical stimulation by interferential therapy (IFT) did not significantly improve bowel movement frequency for chronic constipation. However, IFT did show significant improvements in patient-reported symptoms and quality of life.

Keywords:
chronic constipationdouble blindinterferential therapyquality of liferandomized clinical trialtransabdominal electrical stimulation

More Related Videos

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

1.9K
Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

213

Related Experiment Videos

Last Updated: Jul 30, 2025

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation
04:04

Electroacupuncture Combined with Chinese Medicine Ironing Therapy for Functional Constipation

Published on: July 5, 2024

483
Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease
03:50

Acupoint Application Combined with Acupoint Massage for Treating Constipation in a Patient with Chronic Obstructive Pulmonary Disease

Published on: August 18, 2023

1.9K
Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis
06:19

Chinese Herbal Retention Enema for the Treatment of Ulcerative Colitis

Published on: May 16, 2025

213

Area of Science:

  • Gastroenterology
  • Medical Devices
  • Clinical Trials

Background:

  • Chronic constipation (CC) affects many adults, with nearly half dissatisfied with current treatments.
  • First-line CC treatments include diet, laxatives, and biofeedback, but efficacy is often limited.
  • This study investigated transabdominal electrical stimulation via interferential therapy (IFT) for adult CC.

Purpose of the Study:

  • To assess the effectiveness of transabdominal interferential therapy (IFT) in treating chronic constipation (CC).
  • To evaluate IFT's impact on bowel movement frequency, symptoms, quality of life, and physiological measures in CC patients.

Main Methods:

  • A phase 3, randomized, double-blind, sham-controlled, multicenter trial involving 7 French centers.
  • Primary endpoint: 8-week efficacy based on complete spontaneous bowel movements (CSBMs).
  • Secondary endpoints: Patient Assessment of Constipation Symptoms (PAC-SYM), quality of life, colonic transit time (CTT), manometry, and patient satisfaction.

Main Results:

  • The primary endpoint of a significant difference in 8-week responders between IFT and sham groups was not met.
  • IFT significantly improved overall PAC-SYM scores and symptom reduction compared to sham.
  • No significant differences were found in CTT, anorectal manometry, or patient satisfaction between groups.

Conclusions:

  • Transabdominal interferential therapy (IFT) significantly alleviates symptoms and improves quality of life in chronic constipation patients, despite not meeting the primary endpoint for bowel movement frequency.
  • The findings suggest that patient-reported outcomes are crucial for evaluating new CC treatments.
  • Further research may be needed to refine evaluation methods for novel therapeutic targets in CC.