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Isoimmune neonatal neutropenia
American Journal of Perinatology
|July 1, 1986
Summary
Isoimmune neonatal neutropenia (INN) affects 2 in 1000 live births. This immune disorder requires consideration in all neutropenic infants for accurate diagnosis and treatment.
Area of Science:
- Neonatal Immunology
- Hematology
Background:
- Isoimmune neonatal neutropenia (INN) is a condition where maternal antibodies target infant neutrophils.
- The exact incidence and clinical spectrum of INN require further elucidation.
Purpose of the Study:
- To determine the incidence of INN in a tertiary perinatal center.
- To characterize the clinical and immunologic features of INN.
Main Methods:
- Screening of 1465 newborn infants for neutropenia.
- Evaluation of neutropenic infants for antineutrophil antibodies using EDTA-microagglutination and indirect immunofluorescence.
Main Results:
- Three cases of INN were confirmed among 16 infants with persistent neutropenia.
- The incidence of INN was found to be 2 per 1000 live births.
- INN accounted for 1.5% of special care nursery admissions.
Conclusions:
- INN is not a rare disorder and should be considered in all neutropenic infants, irrespective of infection status.
- Advances in neutrophil-specific antigen systems improve diagnosis and treatment of immune neutropenias.