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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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The Creation of a Rat Model for Osteosarcopenia via Ovariectomy
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Sarcopenia and Cardiovascular Diseases.

Abdulla A Damluji1,2, Maha Alfaraidhy2, Noora AlHajri3

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Sarcopenia, the loss of muscle, worsens with age and chronic illness. Early screening and intervention are key for managing muscle wasting and improving health outcomes, especially in older adults.

Keywords:
body mass indexcardiovascular diseasesolder adultssarcopenia

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Area of Science:

  • Gerontology
  • Muscle Physiology
  • Cardiovascular Medicine

Background:

  • Sarcopenia is characterized by loss of muscle strength, mass, and function.
  • It is often exacerbated by chronic conditions like cardiovascular disease, kidney disease, and cancer.
  • Sarcopenia is linked to accelerated disease progression, increased mortality, falls, and reduced quality of life, particularly in older adults.

Purpose of the Study:

  • Define sarcopenia in the context of muscle wasting disorders.
  • Summarize associations between sarcopenia and cardiovascular diseases.
  • Outline diagnostic and management strategies for sarcopenia.

Main Methods:

  • This review synthesizes existing literature on sarcopenia.
  • It examines the pathophysiologic mechanisms, including anabolic-catabolic imbalance and neuronal degeneration.
  • Diagnostic and management approaches are discussed based on current evidence.

Main Results:

  • Sarcopenia's development is influenced by aging, chronic illness, malnutrition, and immobility.
  • Screening is crucial for individuals with chronic diseases.
  • Body mass index is an inadequate screening tool due to sarcopenic obesity.

Conclusions:

  • Early recognition of sarcopenia allows for interventions to potentially reverse or delay muscle disorder progression.
  • Managing sarcopenia may positively impact cardiovascular outcomes.
  • Further research is needed to address knowledge gaps and advance the field.