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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
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    We developed a precise method using Lewis-Riesenfeld invariance to perfectly distinguish chiral molecules. This technique efficiently separates left-handed and right-handed molecules, offering a robust solution for molecular handedness discrimination.

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    Area of Science:

    • Quantum Chemistry
    • Molecular Spectroscopy
    • Chirality Studies

    Background:

    • Chiral molecules exist as non-superimposable mirror images (enantiomers).
    • Distinguishing between these enantiomers is crucial in pharmaceuticals, agrochemicals, and materials science.
    • Current methods for chiral discrimination can be complex or lack perfect accuracy.

    Purpose of the Study:

    • To propose a novel, accurate, and convenient method for 100% chiral molecule discrimination.
    • To utilize Lewis-Riesenfeld invariance for precise control over molecular populations.
    • To develop a robust technique applicable even in the presence of experimental errors.

    Main Methods:

    • Employing reverse-designed pulse schemes for chiral resolution.
    • Utilizing three-level Hamiltonians derived from Lewis-Riesenfeld invariance.
    • Analyzing population transfer dynamics for different enantiomers from identical initial states.

    Main Results:

    • Achieved complete population transfer to distinct energy levels for left-handed and right-handed molecules.
    • Demonstrated 100% discrimination efficiency between enantiomers.
    • The proposed method shows superior robustness against errors compared to existing shortcut schemes.

    Conclusions:

    • The developed method provides an effective, accurate, and robust means to distinguish molecular handedness.
    • This technique offers a significant advancement in chiral analysis and control.
    • The optimized scheme enhances reliability in practical applications.