Traffic Control: Subversion of Plant Membrane Trafficking by Pathogens
Enoch Lok Him Yuen1, Samuel Shepherd1, Tolga O Bozkurt1
1Department of Life Sciences, Imperial College, London, United Kingdom; email: lok.yuen15@imperial.ac.uk, samuel.shepherd17@imperial.ac.uk, o.bozkurt@imperial.ac.uk.
Annual Review of Phytopathology
|May 15, 2023
Summary
Plant pathogens secrete effectors that reprogram host membrane trafficking, a key process in plant immunity. These pathogens target every step of vesicle transport to subvert plant defenses against disease.
Area of Science:
- Plant Biology
- Molecular Plant-Microbe Interactions
- Cellular Biology
Background:
- Plant immunity relies on coordinated endomembrane transport systems for effective pathogen resistance.
- Pathogens and pests have evolved virulence factors (effectors) to disrupt host membrane trafficking and evade immune responses.
Purpose of the Study:
- To review the mechanisms by which plant pathogens reprogram host vesicle trafficking.
- To provide examples of effector-targeted transport pathways in plant immunity.
- To identify key future research questions in this field.
Main Methods:
- Literature review of current research on plant immunity and pathogen effectors.
- Analysis of effector-mediated manipulation of host membrane trafficking pathways.
- Synthesis of information on vesicle budding, trafficking, and fusion processes targeted by effectors.
Main Results:
- Effectors from various pathogens redundantly target multiple steps of host membrane trafficking.
- Pathogen effectors interfere with vesicle budding, intracellular transport, and membrane fusion.
- Specific examples illustrate how pathogens hijack cellular machinery for their benefit.
Conclusions:
- Membrane trafficking is a critical nexus for plant-pathogen interactions.
- Understanding effector-targeted pathways is crucial for developing novel strategies against plant diseases.
- Further research is needed to fully elucidate the complex interplay between effectors and host transport systems.
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01:23Mechanisms of Drug Absorption: Paracellular, Transcellular, and Vesicular Transport
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02:12Short-distance Transport of Resources
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02:26Defenses Against Pathogens and Herbivores
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