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Network Analysis of the Default Mode Network Using Functional Connectivity MRI in Temporal Lobe Epilepsy
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Subcortical functional connectivity gradients in temporal lobe epilepsy.

Alfredo Lucas1, Sofia Mouchtaris2, Eli J Cornblath3

  • 1Perelman School of Medicine, University of Pennsylvania, United States; Department of Bioengineering, University of Pennsylvania, United States.

Neuroimage. Clinical
|May 15, 2023
PubMed
Summary

Subcortical functional gradients reveal brain differences in temporal lobe epilepsy (TLE). TLE shows an expanded gradient, with distinct hippocampal changes in left-TLE versus right-TLE patients.

Keywords:
ConnectomeDimensionalityFocal epilepsySubcortex

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Area of Science:

  • Neuroimaging
  • Brain Connectivity
  • Epilepsy Research

Background:

  • Functional gradients are used to study brain connectivity differences in disease states, primarily focusing on the cortex.
  • The subcortex is crucial for seizure initiation in temporal lobe epilepsy (TLE).
  • Subcortical functional-connectivity gradients (SFGs) may offer insights into TLE pathophysiology and hemispheric differences.

Purpose of the Study:

  • To calculate and analyze SFGs in patients with TLE and healthy controls.
  • To investigate differences in SFGs between left (L)-TLE and right (R)-TLE.
  • To identify specific subcortical regions and connectivity patterns associated with TLE.

Main Methods:

  • Calculated SFGs using resting-state functional MRI (rs-fMRI) by assessing connectivity profile similarity between subcortical and cortical voxels.
  • Analyzed data from 24 R-TLE patients, 31 L-TLE patients, and 16 controls, matched for clinical variables.
  • Quantified deviations and variance in SFG distributions across subcortical structures to compare L-TLE and R-TLE.

Main Results:

  • Found an expanded principal SFG in TLE patients compared to controls, indicated by increased variance.
  • Observed significant differences in ipsilateral hippocampal gradient distributions between L-TLE and R-TLE patients.
  • Abnormalities in SFGs were localized to the hippocampus ipsilateral to the seizure onset zone.

Conclusions:

  • Expansion of the SFG is a characteristic finding in TLE.
  • Distinct subcortical functional gradient patterns exist between L-TLE and R-TLE.
  • Hippocampal connectivity changes ipsilateral to seizure onset drive these differences, highlighting the role of subcortical structures in TLE.