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Evaluation of testicles by sonoelastography in men recovering after Covid-19 disease
Introduction:
Testicular cells, seminiferous tubule cells, spermatogonia, Leydig and Sertoli cells showing angiotensin-converting enzyme 2 expression have the potential to be targets and to be damaged by the coronavirus. We aimed to use Two-Dimensional Shear Wave Elastography (2D-SWE) as an effective technique to identify parenchymal damage in the testicles of patients recovering from COVID-19 infection.
Methods:
35 Male patients (group 1) who recovered after COVID-19 infection between 4 and 12 weeks were included in this prospective study. Before 2D-SWE, these male patients were confirmed with control Rt-PCR test negativity. In addition, the first Rt-PCR test positivity of these patients was confirmed. A control group was formed of 31 healthy subjects (group 2). These two groups were compared in terms of age, volume of each testis, and SWE values. Ultrasound including SWE was applied to all the testes. A total of 9 measurements were taken as 3 SWE measurements from each third of the testis (superior, mid, inferior) and the average of these was calculated. Data obtained in the study were analyzed statistically. A value of p < 0.05 was accepted as statistically significant.
Results:
The mean SWE values for the right testis and the left testis were determined to be statistically significantly higher in Group 1 than in Group 2, respectively (p < 0.001, p < 0.001).
Conclusion:
There is an increase in testicular stiffness in males who have recovered from COVID-19 infection. The underlying cause of testicular damage is changes at the cellular level. The 2D-SWE technique can predict potential testicular parenchymal damage in male patients recovering from COVID-19 infection.
Implications For Practice:
Two-Dimensional Shear Wave Elastography (2D-SWE) seems to be a promising imaging technique in the evaluation of testis parenchyma.
Insights
Men recovering from COVID-19 show increased testicular stiffness. Two-Dimensional Shear Wave Elastography (2D-SWE) can identify this potential parenchymal damage, aiding in assessing male reproductive health post-infection.
Area of Science:
- Reproductive Medicine
- Medical Imaging
- Infectious Diseases
Background:
- COVID-19 infection can target testicular cells expressing angiotensin-converting enzyme 2.
- Potential for testicular damage exists in males recovering from COVID-19.
- Assessing testicular health post-COVID-19 is crucial.
Purpose of the Study:
- To evaluate the effectiveness of Two-Dimensional Shear Wave Elastography (2D-SWE) in identifying testicular parenchymal damage.
- To compare testicular stiffness in males recovered from COVID-19 with healthy controls.
- To determine if 2D-SWE can predict testicular damage after COVID-19 infection.
Main Methods:
- A prospective study involving 35 male patients recovered from COVID-19 (Group 1) and 31 healthy controls (Group 2).
- All participants underwent ultrasound with 2D-SWE, with 9 measurements taken per testis.
- Statistical analysis compared age, testicular volume, and SWE values between groups.
Main Results:
- Mean SWE values were significantly higher in both the right and left testes of the COVID-19 recovered group compared to the control group (p < 0.001 for both).
- This indicates increased testicular stiffness in males after COVID-19 recovery.
- The findings were statistically significant.
Conclusions:
- Testicular stiffness increases in males who have recovered from COVID-19 infection.
- Cellular-level changes are the likely cause of testicular damage.
- 2D-SWE is a promising technique for predicting and evaluating potential testicular parenchymal damage in post-COVID-19 male patients.
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