Benzothiazole-based novel fluorescence probe sensing 1, 3-diaminopropane

Area of Science:

• Analytical Chemistry
• Chemical Sensing
• Organic Synthesis

Background:

• Amines are vital in biological systems, industry, and agriculture.
• Accurate amine detection is crucial for food safety and medical diagnostics.
• Developing selective and sensitive amine sensors remains an ongoing challenge.

Purpose of the Study:

• To design and synthesize a novel Schiff base probe, designated HL.
• To evaluate the probe's efficacy as a selective fluorescent sensor for 1,3-diaminopropane.
• To investigate the sensing mechanism and assess practical applicability.

Main Methods:

• Schiff base probe HL synthesis and characterization.
• Fluorescence spectroscopy for amine detection in various solvents.
• Mass spectrometry, NMR, and DFT/TD-DFT calculations for mechanism elucidation.
• Spiking experiments in real water samples and paper strip tests.

Main Results:

• Successful synthesis of the Schiff base probe HL.
• Exclusive turn-on fluorescence response observed for 1,3-diaminopropane.
• Achieved micromolar limits of detection in diverse solvents, including water.
• Proposed sensing mechanism supported by spectroscopic and computational data.
• Demonstrated practical utility through real water sample analysis and paper strip assays.

Conclusions:

• The Schiff base probe HL is a highly effective sensor for 1,3-diaminopropane detection.
• The probe exhibits excellent sensitivity and selectivity with a turn-on fluorescence mechanism.
• Its performance in real samples and on paper strips highlights its potential for practical applications in food quality control and diagnostics.