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Related Concept Videos

Mouse Models of Cancer Study02:43

Mouse Models of Cancer Study

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Mice have long served as models for studying human biology and pathology because of their phylogenetic and physiological similarity with humans. They are also easy to maintain and breed in the laboratory, and hence, many inbred strains are now available for research. Studies on mice have contributed immeasurably to our understanding of cancer biology.
The development of transgenic, knockout, and knock-in mice has led to an exponential increase in their use as model organisms in research,...
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Updated: Jul 30, 2025

Orthotopic Transplantation of Breast Tumors as Preclinical Models for Breast Cancer
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Experimental models for preclinical cancer research.

Stephanie Ma1

  • 1School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.

Experimental Cell Research
|May 15, 2023
PubMed
Summary

Advancements in experimental models like zebrafish, mouse, and organoids are improving human cancer research. These sophisticated models offer new perspectives for developing effective cancer therapies globally.

Area of Science:

  • Oncology and Translational Research
  • Biomedical Engineering
  • Genetics and Genomics

Background:

  • Human cancers represent a significant global health challenge, historically limited by inadequate experimental models.
  • Recent advancements have led to more sophisticated and reliable experimental models for human cancer research.

Discussion:

  • This special issue features seven short reviews on diverse human cancer types, including leukemia, breast, ovarian, and liver cancers.
  • Investigational approaches utilizing zebrafish, mouse models, and organoids are critically examined.
  • The strengths and limitations of each experimental model are highlighted to guide future research.

Key Insights:

  • Sophisticated experimental models are crucial for advancing our understanding of human cancers.

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  • Zebrafish, mouse models, and organoids offer distinct advantages and disadvantages for specific cancer research applications.
  • Comparative analysis of these models provides valuable insights for selecting appropriate research tools.

    • Outlook:

    • Continued development and refinement of experimental cancer models are essential for accelerating therapeutic discovery.
    • Integrating knowledge from various model systems will foster a more comprehensive approach to cancer treatment.
    • Future research will likely leverage the unique strengths of zebrafish, mouse, and organoid models to overcome existing challenges in oncology.