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Long-Term Follow-Up of Daily Life Functioning After Pediatric Intensive Care Unit Admission

Eleonore S V de Sonnaville1, Marsh Kӧnigs2, Cornelieke S H Aarnoudse-Moens2

  • 1Amsterdam UMC, University of Amsterdam, Emma Children's Hospital, Department of Pediatric Intensive Care, Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands; Amsterdam UMC, University of Amsterdam, Emma Children's Hospital, Department of Pediatrics, Emma Children's Hospital Amsterdam UMC Follow Me program & Emma Neuroscience Group, Amsterdam Reproduction and Development Research Institute, Amsterdam, The Netherlands.

The Journal of Pediatrics
|May 15, 2023
PubMed

Insights

Pediatric intensive care unit (PICU) admission can negatively impact children's academic performance and quality of life. Lower intelligence may be a key factor in these long-term neurocognitive and daily functioning difficulties.

Area of Science:

  • Pediatric critical care medicine
  • Neuroscience
  • Developmental psychology

Background:

  • Pediatric intensive care unit (PICU) admission may have lasting effects on children's daily functioning.
  • Neurocognitive outcomes might play a role in mediating these long-term effects.
  • Understanding these impacts is crucial for post-PICU care.

Purpose of the Study:

  • To investigate the long-term impact of pediatric intensive care unit (PICU) admission on daily life functioning.
  • To explore the mediating role of neurocognitive outcomes in this relationship.
  • To assess behavioral, emotional, academic, and quality of life outcomes.

Main Methods:

  • Cross-sectional observational study comparing children with prior PICU admission (n=65) to healthy peers (n=76).
  • Participants were aged 6-12 years; PICU admission occurred at age ≤1 year for bronchiolitis requiring mechanical ventilation.
  • Mediation analysis was used to assess the role of neurocognitive outcomes (IQ, verbal memory) in daily functioning.

Main Results:

  • Children with prior PICU admission showed poorer academic performance and school-related quality of life compared to controls.
  • Lower full-scale IQ (FSIQ) was linked to worse academic performance and school-related quality of life within the patient group.
  • FSIQ mediated the effects of PICU admission on reading comprehension and arithmetic performance.

Conclusions:

  • PICU admission poses a risk for long-term adverse outcomes in academic performance and school-related quality of life.
  • Lower intelligence appears to contribute to academic challenges following PICU admission.
  • Monitoring daily life and neurocognitive functioning post-PICU is essential.
Abstract

Keywords:
academic performancebehavioral and emotional functioningbronchiolitishealth-related quality of lifeneurocognitionneurocognitive functioning

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