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Evaluation of in vitro activity of ceftaroline against pathogens associated with community-acquired pneumonia: ATLAS

Eric Utt1, Michal Kantecki2, Guillermo Cabezas-Camarero3

  • 1Pfizer, Inc., Groton, Connecticut.

Journal of Global Antimicrobial Resistance
|May 15, 2023
PubMed
Abstract

Insights

Ceftaroline demonstrates high antimicrobial susceptibility against common respiratory pathogens like Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae. This finding supports its role in treating community-acquired pneumonia across all age groups.

Area of Science:

  • Infectious Diseases
  • Microbiology
  • Pharmacology

Background:

  • Community-acquired pneumonia (CAP) requires effective antimicrobial therapies.
  • Ceftaroline is a key therapeutic option for CAP.
  • Understanding pathogen susceptibility is crucial for treatment guidelines.

Purpose of the Study:

  • To evaluate ceftaroline antimicrobial susceptibility.
  • To analyze susceptibility against Staphylococcus aureus, Streptococcus pneumoniae, and Haemophilus influenzae.
  • To report findings across different age groups (0-18, 19-65, >65 years).

Main Methods:

  • Utilized isolates from the ATLAS program (2017-2019).
  • Performed antimicrobial susceptibility testing per EUCAST/CLSI guidelines.
  • Collected respiratory tract isolates from global sources.

Main Results:

  • High ceftaroline susceptibility observed for S. aureus (89.08%-97.83%), S. pneumoniae (98.25%-99.77%), and H. influenzae (89.53%-99.70%).
  • Isolates from younger age groups (0-18 years) showed the highest susceptibility rates.
  • Methicillin-susceptible S. aureus (MSSA) and penicillin-intermediate S. pneumoniae (PISP) exhibited near-100% susceptibility.

Conclusions:

  • Ceftaroline exhibits high susceptibility against major respiratory pathogens.
  • Age did not significantly diminish ceftaroline's effectiveness.
  • Results support ceftaroline's continued use in CAP treatment.
Keywords:
Antimicrobial activityAntimicrobial resistanceCeftarolineCommunity-acquired pneumoniaStaphylococcus aureusSusceptibility

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