Related Experiment Video
Updated: Jul 30, 2025

Cutoff Value of Phase Angle by Bioelectrical Impedance Analysis at Admission as a Prognostic Factor in Patients with Acute Heart Failure
Published on: June 10, 2025
Medication Adherence and Its Associated Factors Among Outpatients with Heart Failure
Anan S Jarab1,2, Walid A Al-Qerem3, Hanan Walid Hamam1
1Department of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology, Irbid, 22110, Jordan.
Insights
Poor medication adherence is common in heart failure patients. Interventions should target those with low education, on anticoagulants, or not on statins or ACEI/ARBs to improve outcomes.
Area of Science:
- Cardiology
- Pharmacology
- Public Health
Background:
- Medication adherence is crucial for effective heart failure (HF) management.
- Poor adherence to HF medications significantly hinders desired health outcomes.
- Identifying non-adherence factors is key to developing targeted interventions.
Purpose of the Study:
- To assess medication adherence rates among heart failure patients in Jordan.
- To identify factors associated with medication non-adherence in this population.
Main Methods:
- A cross-sectional study was conducted in Jordanian outpatient cardiology clinics (August 2021-April 2022).
- Data collected via medical records and questionnaires included socio-demographics, biomedical, disease, and medication characteristics.
- Medication adherence was measured using the 4-item Morisky Medication Adherence Scale; multinomial logistic regression analyzed non-adherence factors.
Main Results:
- 92.5% of 427 HF patients exhibited low to moderate medication adherence.
- Higher education and absence of side effects correlated with moderate adherence.
- Use of statins or ACEIs/ARBs was linked to higher adherence; non-use of anticoagulants also predicted better adherence.
Conclusions:
- Low medication adherence is prevalent in Jordanian heart failure patients.
- Intervention programs should focus on improving patient perception of medications.
- Targeting interventions for patients with low education, on anticoagulants, or not on statins/ACEIs/ARBs is recommended.
Background:
Poor adherence to heart failure (HF) medications represents a major barrier to achieve the desired health outcomes in those patients.
Objective:
To assess medication adherence and to explore the factors associated with medication non-adherence among patient with HF in Jordan.
Methods:
The current cross-sectional study was conducted at the outpatient cardiology clinics at two main hospitals in Jordan from August 2021 through April 2022. Variables including socio-demographics, biomedical variables, in addition to disease and medication characteristics were collected using medical records and custom-designed questionnaire. Medication adherence was assessed using the 4-item Morisky Medication Adherence Scale. Multinomial logistic regression analysis was performed to identify the factors that are significantly and independently associated with medication non-adherence.
Results:
Of the 427 participating patients, 92.5% had low to moderate medication adherence. Results of the regression analysis revealed that that patients who had higher education level (OR=3.36; 95% CI 1.08-10.43; P=0.04) and were not suffering from medication-related side effects (OR=4.7; 95% CI 1.91-11.5; P=0.001) had significantly higher odds of being in the moderate adherence group. Patients who were taking statins (OR=16.59; 95% CI 1.79-153.98; P=0.01) or ACEIs/ ARBs (OR=3.95; 95% CI 1.01-15.41; P=0.04) had significantly higher odds of being in the high adherence group. Furthermore, Patients who were not taking anticoagulants had higher odds of being in the moderate (OR=2.77; 95% CI 1.2-6.46; P=0.02) and high (OR=4.11; 95% CI 1.27-13.36; P=0.02) adherence groups when compared to patients who were taking anticoagulants.
Conclusion:
The poor medication adherence in the present study sheds the light on the importance of implementing intervention programs which focus on improving patients' perception about the prescribed medications particularly for patients who have low educational levels, receive an anticoagulant, and do not receive a statin or an ACEI/ ARB.
Related Concept Videos
Heart Failure VI: Adjunct Therapies
Heart Failure V: Medical Management
Heart Failure VII: Nursing Interventions
Heart Failure Drugs: Inhibitors of Renin-Angiotensin System
Cardiomyopathy VI: Nursing Management
Heart Failure Drugs: Diuretics

