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Maternal risk factors for posterior urethral valves
Loes F M van der Zanden1, Sander Groen In 't Woud1, Iris A L M van Rooij1
1Department for Health Evidence, Radboud university medical center, Nijmegen, Netherlands.
Frontiers in Pediatrics
|May 15, 2023
Summary
Maternal factors like family history of CAKUT, low maternal age, and preexisting hypertension are linked to posterior urethral valves (PUV) in male infants. Higher maternal age and gestational hypertension may reduce PUV risk.
Area of Science:
- Pediatric Urology
- Congenital Anomalies
- Maternal Health
Background:
- Posterior urethral valves (PUV) is a congenital obstruction affecting 1 in 4,000 male births.
- PUV is a multifactorial disorder influenced by genetic and environmental factors.
- Investigating maternal risk factors is crucial for understanding PUV etiology.
Purpose of the Study:
- To identify maternal risk factors associated with the development of posterior urethral valves (PUV).
Main Methods:
- A case-control study included 407 PUV patients and 814 controls.
- Maternal questionnaires collected data on family history, conception methods, and maternal health factors.
- Conditional logistic regression was used to estimate adjusted odds ratios for risk factors.
Main Results:
- Positive family history of CAKUT and low maternal age (<25 years) increased PUV risk.
- Higher maternal age (>35 years) was associated with a reduced risk.
- Preexisting hypertension showed a potential increase in risk, while gestational hypertension showed a potential decrease.
Conclusions:
- Family history, low maternal age, and preexisting hypertension are potential risk factors for PUV.
- Higher maternal age and gestational hypertension may be protective.
- Further research is needed on maternal age, hypertension, and assisted reproductive techniques (ART) in PUV development.
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