Miconazole prolongs murine skin graft survival

The effects of miconazole, a broad spectrum anti-fungal compound, on the immune response was studied in mice. At the non-toxic dose of 300 mg/kg per day, there was minimal suppression of the antibody response to sheep red blood cells. In contrast, there was a marked prolongation of skin graft survival from 13.6 +/- 1.8 days (mean +/- s.d.) in untreated mice to 18.6 +/- 3.5 dyas in the treated group. Miconazole may be of use in clinical transplantation.