Related Experiment Video
Updated: Jul 30, 2025
12:19
Monitoring the Cancer-Immunity Cycle and Exploring Tumor Microenvironment Dynamics
Published on: June 7, 2024
1.1K
Breast Cancer Immunity: It is TIME for the Next Chapter
Daniela F Quail1,2, Morag Park1,3, Alana L Welm4
1Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, Quebec H3A 1A3, Canada.
Cold Spring Harbor Perspectives in Medicine
|May 15, 2023
Summary
Understanding the tumor immune microenvironment (TIME) in breast cancer reveals immune system roles in tumor growth and evasion. Advanced single-cell genomics and spatial proteomics offer new insights for developing effective treatments.
Area of Science:
- Oncology
- Immunology
- Genomics
Background:
- The tumor immune microenvironment (TIME) significantly influences breast cancer progression.
- Immune cells like T cells and macrophages play crucial roles in controlling breast cancer.
- Recent technological advancements allow for a more granular understanding of the TIME.
Purpose of the Study:
- To detail the immune response against breast cancer.
- To examine the heterogeneity of the TIME across different breast cancer subtypes.
- To explore how preclinical models aid in understanding tumor immune evasion and clearance.
Main Methods:
- Single-cell genomics
- Spatial proteomics
- Analysis of preclinical models
- Comparative analysis of human and murine models
Main Results:
- Identification of critical determinants of disease progression within the TIME.
- Elucidation of the complex interplay between immune components and breast tumor growth.
- Revealing previously unappreciated complexity in breast cancer immunology through advanced technologies.
Conclusions:
- The immune system plays a multifaceted role in breast cancer, offering therapeutic targets.
- Translational research leveraging TIME analysis is key to improving clinical outcomes.
- Future research should focus on cellular and spatial levels for deeper insights into breast cancer immunology.
Related Concept Videos
01:27Tumor Immunotherapy
587
Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.
587
01:30Cancer Vaccines
449
Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
449
02:53Adaptive Mechanisms in Cancer Cells
5.9K
Cancer cells accumulate genetic changes at an abnormally rapid rate due to the defects in the DNA repair mechanisms. From an evolutionary perspective, such genetic instability is advantageous for cancer development. Mutant cell lines accumulate a series of beneficial mutations that contribute to their progression into cancer.
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
Some of the advantages that cancer cells have on normal cells include - enhanced ability to divide without terminally differentiating, induce new blood vessel formation,...
5.9K
02:59Cancer Prevention
6.2K
Several factors can increase the risk of cancer in an individual. About 50% of cancer cases can be prevented by adopting a healthy lifestyle, regular exercise, eating healthy, and following a modest cancer prevention diet. Epidemiological studies have consistently shown that populations with vegetable and fruit-rich diets have reduced the incidence of cancer. On the other hand, populations who have a diet rich in animal fat, red meat, junk food, or high calories are predisposed to cancer.
Some...
Some...
6.2K
01:27Cytotoxic T Cells-mediated Immune Response
1.0K
Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
1.0K
01:23Immunological Memory
714
Immunological memory, a pivotal pillar of the adaptive immune system, is responsible for the body's ability to remember and respond more swiftly and effectively to previously encountered pathogens. This remarkable feature is what makes vaccines so effective in preventing diseases.
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
What is Immunological Memory?
Immunological memory is an integral function of the immune system that allows it to recognize and react more rapidly and effectively to pathogens previously encountered. This feature...
714