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Updated: Jul 13, 2026

An In Vitro Organ Culture Model of the Murine Intervertebral Disc
Published on: April 11, 2017
Intervertebral disc-on-a-chip: a precision engineered toolbox for low back pain studies
Javad Tavakoli1, Ashish D Diwan2, Joanne L Tipper3
1School of Biomedical Engineering, University of Technology Sydney, Sydney, NSW, Australia; SpineLabs, St George and Sutherland Clinical School, University of New South Wales, Sydney, NSW, Australia.
Abstract:
Current in vitro intervertebral disc (IVD) models do not fully recapitulate the complex mechanobiology of native tissue, and so far there is no strategy to effectively evaluate IVD regeneration. The development of a modular microfluidic on-chip model is expected to enhance the physiological relevance of experimental data leading to successful clinical outcomes.
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