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Related Concept Videos

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion01:27

Glucose Homeostasis: Pancreatic Islets and Insulin Secretion

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The pancreatic islets comprising only 1%-2% of the volume are highly vascularized and innervated mini-organs. They contain five endocrine cell types, including β cells that secrete insulin, which is synthesized as a single polypeptide chain, preproinsulin, processed to proinsulin, and finally to insulin and C-peptide. This process is complex and regulated, involving the Golgi complex, the endoplasmic reticulum, and the secretory granules of the β cell.
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Single-cell expression profiling of islets generated by the Human Pancreas Analysis Program

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  • 1Department of Genetics, University of Pennsylvania Perelman School of Medicine, Philadelphia, PA, USA.

Nature Metabolism
|May 15, 2023
PubMed
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No abstract available in PubMed .

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