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Related Experiment Video

Updated: Jul 30, 2025

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Long-term Behavioral and Reproductive Consequences of Embryonic Exposure to Low-dose Toxicants

Published on: March 6, 2018

Endosulfan affects embryonic development synergistically under elevated ambient temperature.

Tanjeena Zaman^1,2, Talukdar Mohammad Fahad¹, Masud Rana¹

¹Department of Pharmacy, University of Rajshahi, Rajshahi, 6205, Bangladesh.

Environmental Science and Pollution Research International

|May 15, 2023

Summary

This summary is machine-generated.

Elevated temperatures worsen endosulfan

Keywords:

Embryonic alteration Endosulfan HSP Temperature Zebrafish

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Area of Science:

Environmental Toxicology
Developmental Biology
Zebrafish Models

Background:

Endosulfan is a toxic pesticide with known developmental effects.
Elevated ambient temperatures can exacerbate toxicant impacts.
Zebrafish are a sensitive model for studying developmental toxicity.

Purpose of the Study:

To investigate the combined effects of endosulfan exposure and elevated temperature on zebrafish development.
To understand the synergistic toxicity of endosulfan under thermal stress.

Main Methods:

Zebrafish embryos were exposed to endosulfan in E3 medium.
Embryos were incubated at standard (28.5°C) and elevated (35°C) temperatures.
Developmental morphology and gene expression (hsp70, p16, smp30) were analyzed.

Main Results:

Elevated temperature alone caused significant mortality and malformations in early zebrafish embryos.
Concurrent exposure to endosulfan and elevated temperature resulted in more severe developmental defects, including brain malformations.
Gene expression analysis revealed synergistic effects on stress-related genes.

Conclusions:

Elevated ambient temperature significantly enhances the developmental toxicity of endosulfan in zebrafish.
The combination of endosulfan and heat stress poses a greater risk to aquatic organism development.
This study highlights the critical role of environmental factors in modulating pesticide toxicity.