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Updated: Jul 30, 2025

Exploring Biomolecular Interaction Between the Molecular Chaperone Hsp90 and Its Client Protein Kinase Cdc37 using Field-Effect Biosensing Technology

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Published on: March 31, 2022

FRET Based Biosensor: Principle Applications Recent Advances and Challenges.

Awadhesh Kumar Verma¹, Ashab Noumani¹, Amit K Yadav¹

¹Lab D NanoBiolab, Special Centre for Nanoscience, Jawaharlal Nehru University, New Delhi 110067, India.

Diagnostics (Basel, Switzerland)

|May 16, 2023

Summary

This summary is machine-generated.

Förster resonance energy transfer (FRET)-based biosensors offer precise detection of biomolecules and environmental changes. This review explores FRET biosensor principles, diverse applications, and emerging technologies like AI and IoT.

Keywords:

FRET biosensor fluorescent QDs fluorophore foster radius

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Area of Science:

Biochemistry
Cell Biology
Nanotechnology

Background:

Förster resonance energy transfer (FRET) is a photophysical process involving energy transfer between donor and acceptor fluorophores.
FRET-based biosensors utilize engineered donor and acceptor molecules (fluorescent proteins, quantum dots, small molecules) for sensitive detection.
Changes in the distance between donor and acceptor, induced by target molecules, alter FRET efficiency and signal output.

Purpose of the Study:

To provide a comprehensive review of FRET-based biosensors.
To detail the underlying principles and diverse applications of FRET biosensors.
To discuss recent advancements and challenges in FRET biosensor technology.

Main Methods:

Review of existing literature on FRET biosensors.
Analysis of FRET principles and mechanisms.
Exploration of various FRET biosensor applications and emerging technologies.

Main Results:

FRET biosensors enable specific detection of biomolecules and microenvironment changes.
Applications span point-of-need diagnostics, wearable devices, single-molecule studies, and environmental monitoring (ions, pH).
Recent integration of artificial intelligence (AI) and Internet of Things (IoT) enhances FRET biosensor capabilities.

Conclusions:

FRET biosensors are versatile tools with broad applications in life sciences and diagnostics.
The integration of advanced technologies like AI and IoT promises further innovation in FRET biosensor development.
Ongoing research addresses challenges to optimize FRET biosensor performance and expand their utility.