Related Experiment Video

Updated: Jul 30, 2025

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies
06:38

A Syngeneic Mouse Model of Metastatic Renal Cell Carcinoma for Quantitative and Longitudinal Assessment of Preclinical Therapies

Published on: April 12, 2017

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Immune Checkpoint Inhibitors in Renal Cell Carcinoma: Molecular Basis and Rationale for Their Use in Clinical

Francesco Lasorsa1, Nicola Antonio di Meo1, Monica Rutigliano1

  • 1Urology, Andrology and Kidney Transplantation Unit, Department of Precision and Regenerative Medicine and Ionian Area, University of Bari "Aldo Moro", 70124 Bari, Italy.

Biomedicines
|May 16, 2023
PubMed

Insights

Immunotherapy, particularly immune checkpoint inhibitors (ICIs), shows promise for treating renal cell carcinoma (RCC). Combining ICIs with other treatments offers good response rates for this often chemoresistant cancer.

Area of Science:

  • Oncology
  • Immunology

Background:

  • Renal cell carcinoma (RCC) is a common cancer with significant metastatic and recurrence rates.
  • RCC is considered chemoresistant but highly immunogenic, highlighting the potential of immunotherapy.
  • Understanding immunosurveillance mechanisms has led to the development of novel cancer treatments.

Purpose of the Study:

  • To review the mechanisms of immunity modulation and immune checkpoints in RCC.
  • To discuss potential therapeutic strategies for renal cancer treatment.

Main Methods:

  • Review of existing literature on RCC, immunology, and immunotherapy.
  • Analysis of clinical trial data regarding immune checkpoint inhibitors (ICIs) and tyrosine kinase inhibitors in RCC treatment.

Main Results:

  • Immunotherapy, especially ICIs, has revolutionized RCC treatment.
  • Combination therapies involving ICIs show very good response rates.
  • ICIs modulate the immune system's response against RCC.

Conclusions:

  • ICIs represent a significant advancement in managing renal cell carcinoma.
  • Further research into immune modulation and therapeutic strategies is crucial for improving RCC patient outcomes.
Keywords:
cancer immune escapeimmune-checkpoint inhibitorsimmunotherapyrenal cancertherapy

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