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Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
Published on: April 13, 2015
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Multiple Actions of Telomerase Reverse Transcriptase in Cell Death Regulation
Anastasia I Palamarchuk1, Elena I Kovalenko1, Maria A Streltsova1
1Shemyakin & Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Ul. Miklukho-Maklaya 16/10, 117997 Moscow, Russia.
Biomedicines
|May 16, 2023
Summary
Telomerase reverse transcriptase (TERT) has functions beyond telomere maintenance, impacting cell survival and stress responses. This review explores TERT
Area of Science:
- Cell Biology
- Molecular Biology
- Biochemistry
Background:
- Telomerase reverse transcriptase (TERT) is a key component of telomerase, traditionally known for telomere maintenance.
- Emerging evidence highlights TERT's diverse roles beyond telomere lengthening, including involvement in various cellular signaling pathways.
- TERT's varied intracellular locations correlate with its multifaceted functional activities.
Purpose of the Study:
- To comprehensively review the role of TERT in regulating cell death.
- To elucidate TERT's interactions with signaling pathways crucial for cell survival and stress response.
- To provide a deeper understanding of TERT's non-canonical functions in cellular processes.
Main Methods:
- Literature review of existing studies on TERT function.
- Analysis of data linking TERT to cell death regulation.
- Examination of TERT's interactions with signaling pathways involved in cell survival and stress.
Main Results:
- TERT participates in cell stress responses, gene regulation, and mitochondrial function.
- Upregulation of TERT and telomerase activity are associated with enhanced cell survival and persistence, particularly in cancer.
- TERT influences cell death pathways through interactions with multiple signaling cascades.
Conclusions:
- TERT plays a significant role in cell death regulation, extending beyond its canonical telomere maintenance function.
- TERT's involvement in cell survival and stress response pathways is critical for cellular persistence.
- Further research into TERT's diverse functions can offer new insights into cancer biology and therapeutic strategies.
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