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Optical Coherence Tomography Based Biomechanical Fluid-Structure Interaction Analysis of Coronary Atherosclerosis Progression
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Atherosclerosis, Cardiovascular Disease, and COVID-19: A Narrative Review

Carles Vilaplana-Carnerero1,2,3, Maria Giner-Soriano1,3, Àngela Dominguez2,4

  • 1Fundació Institut Universitari per a la Recerca a l'Atenció Primària de Salut Jordi Gol i Gurina (IDIAPJGol), 08007 Barcelona, Spain.

Biomedicines
|May 16, 2023
PubMed

Insights

COVID-19 negatively impacts individuals with atherosclerosis and cardiovascular diseases (CVDs), potentially worsening outcomes. Cardiovascular drugs may also influence COVID-19 prognosis, highlighting a complex interplay.

Area of Science:

  • Cardiovascular Medicine
  • Infectious Diseases
  • Inflammation

Background:

  • Atherosclerosis is a chronic inflammatory arterial disease underlying cardiovascular diseases (CVDs), a leading global cause of death.
  • Emerging evidence suggests a complex, bidirectional relationship between COVID-19 and atherosclerosis/CVDs.
  • COVID-19 significantly worsens prognosis for patients with pre-existing CVDs and can lead to new CVD diagnoses.

Purpose of the Study:

  • To review recent studies on the bidirectional link between COVID-19 and atherosclerosis.
  • To summarize the impact of cardiovascular drugs on COVID-19 outcomes.
  • To explore how understanding this relationship can improve patient risk stratification and management.

Main Methods:

  • Narrative review of current scientific literature.
  • Synthesis of evidence on COVID-19's effects on atherosclerosis and CVD.
  • Discussion of the role of cardiovascular medications in COVID-19.

Main Results:

  • COVID-19 prognosis is poorer in individuals with CVD.
  • New-onset CVD has been observed in patients post-COVID-19 infection.
  • Cardiovascular drugs' influence on COVID-19 outcomes requires further investigation.

Conclusions:

  • Atherosclerosis, CVD, and COVID-19 are interconnected, impacting patient outcomes.
  • Further research is needed to elucidate the precise mechanisms and therapeutic implications.
  • Improved understanding can lead to better identification of at-risk individuals and enhanced management strategies.

Keywords:
COVID-19atherosclerosisbidirectional linkcardiovascular diseasecardiovascular disease treatmentslong COVID

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