Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Gene-Environment Interactions01:20

Gene-Environment Interactions

382
Gene expression is a dynamic process that is significantly influenced by environmental factors. This interaction underlies the complex nature of biological development and the phenotypic differences observed among individuals, even among those with identical genetic makeups. Factors such as radiation, temperature, behavior, nutrition, and stress play pivotal roles in determining how genes are expressed. The concept of the reaction range is central to understanding this interaction. It posits...
382
Human Genetics01:28

Human Genetics

635
Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
The complex relationship between genetics and psychology is observable through common biological components such...
635
Background and Environment Affect Phenotype02:27

Background and Environment Affect Phenotype

6.6K
Although the genetic makeup of an organism plays a major role in determining the phenotype, there are also several environmental factors, such as temperature, oxygen availability, presence of mutagens, that can alter an organism’s phenotype.
An example of how genetic background affects phenotype can be seen in horses. The Extension gene in horses is responsible for their coat color. A wild-type gene (EE) produces black pigment in the coat, while a mutant gene (ee) produces red pigment. A...
6.6K
Behavioral Genetics and Its Designs01:23

Behavioral Genetics and Its Designs

435
Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
The primary methodologies used in behavior genetics include family studies, twin studies, and adoption studies, each providing unique...
435
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

107
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
107
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

150
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
150

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The role of <i>trans</i>-acting factors in the pathogenesis of common psychiatric disorders.

Epigenetics·2026
Same author

Vafidemstat: a lysine-specific demethylase 1A inhibitor that shows promise for treating neuropsychiatric disorders.

Epigenetics reports·2025
Same author

Inhibition of Contractility of Isolated Caprine Detrusor by the Rho Kinase Inhibitor Fasudil and Reversal by the Guanylyl Cyclase Inhibitor ODQ.

Current therapeutic research, clinical and experimental·2025
Same author

Histone monoaminylation is a novel epigenetic mechanism in psychiatric disorders.

Frontiers in molecular neuroscience·2025
Same author

The Role of Epigenetics in the Pathogenesis and Potential Treatment of Obsessive-compulsive Disorder.

Current neuropharmacology·2025
Same author

Editorial: Epigenetics and neurodevelopment in psychiatry.

Frontiers in genetics·2024

Related Experiment Video

Updated: Jul 30, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.6K

Genome-Environment Interactions and Psychiatric Disorders.

Jacob Peedicayil1

  • 1Department of Pharmacology & Clinical Pharmacology, Christian Medical College, Vellore 632 002, India.

Biomedicines
|May 16, 2023
PubMed
Summary

Environmental factors impact the genome through epigenetic changes, influencing psychiatric disorders like schizophrenia and depression. These factors also offer therapeutic targets for treatment.

Keywords:
environmentepigeneticgeneticgenomepsychiatric disorder

More Related Videos

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

16.1K
Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

8.8K

Related Experiment Videos

Last Updated: Jul 30, 2025

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease
08:09

Gene-environment Interaction Models to Unmask Susceptibility Mechanisms in Parkinson's Disease

Published on: January 7, 2014

7.6K
Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting
11:31

Rapid Fractionation and Isolation of Whole Blood Components in Samples Obtained from a Community-based Setting

Published on: November 30, 2015

16.1K
Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice
09:35

Environmental Modulations of the Number of Midbrain Dopamine Neurons in Adult Mice

Published on: January 20, 2015

8.8K

Area of Science:

  • Neuroscience
  • Genetics
  • Psychiatry

Background:

  • Environmental factors interact with the genome via epigenetic mechanisms.
  • These interactions contribute to the pathogenesis of psychiatric disorders.

Purpose of the Study:

  • To review how environmental factors epigenetically influence psychiatric disorders.
  • To explore epigenetic therapeutic strategies for psychiatric conditions.

Main Methods:

  • Narrative review of articles from PubMed and Google Scholar.
  • Searched for gene, genome, environment, psychiatric disorder, epigenetic, and interaction.
  • Included articles published between January 2000 and December 2022.

Main Results:

  • Environmental factors like social determinants, stress, poverty, migration, urban living, birth complications, substance abuse, microbiota, and infections epigenetically affect psychiatric disorder pathogenesis.
  • Therapeutic interventions including drugs, psychotherapy, electroconvulsive therapy, and exercise also act epigenetically.

Conclusions:

  • Epigenetic modifications link environmental factors to psychiatric disorders.
  • Understanding these epigenetic mechanisms is crucial for developing effective treatments.