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Preterm Birth, Developmental Smoke/Nicotine Exposure, and Life-Long Pulmonary Sequelae
Chie Kurihara1, Katherine M Kuniyoshi1, Virender K Rehan1
1Department of Pediatrics, The Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Children (Basel, Switzerland)
|May 16, 2023
Summary
Preterm birth and perinatal nicotine exposure significantly increase asthma risk in offspring. These effects may even impact future generations through epigenetic changes.
Area of Science:
- Pulmonary Medicine
- Neonatology
- Genetics
Background:
- Preterm birth is a leading cause of neonatal respiratory morbidity.
- Perinatal exposure to tobacco and nicotine is a significant environmental risk factor for respiratory diseases.
- Emerging evidence suggests transgenerational effects on respiratory health.
Purpose of the Study:
- To review pulmonary complications associated with preterm birth.
- To examine the impact of perinatal tobacco/nicotine exposure on offspring respiratory health.
- To explore the potential for transgenerational pulmonary effects.
Main Methods:
- Literature review of studies on preterm birth and respiratory outcomes.
- Analysis of research on developmental tobacco/nicotine exposure and asthma.
- Investigation of epigenetic mechanisms in transgenerational pulmonary effects.
Main Results:
- Preterm birth is linked to increased asthma risk later in life.
- Developmental nicotine exposure adversely affects offspring lung development and asthma susceptibility.
- Perinatal tobacco/nicotine exposure may induce transgenerational pulmonary changes via germline epigenetics.
Conclusions:
- Pulmonary issues from preterm birth and perinatal nicotine exposure pose long-term risks.
- Transgenerational effects on respiratory health warrant further investigation.
- Interventions targeting perinatal exposures are crucial for preventing long-term respiratory morbidity.
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