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Poly(iminocarbonates) as potential biomaterials.

J Kohn, R Langer

    Biomaterials
    |May 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    New poly(iminocarbonates) based on hydroquinone and Bisphenol A degrade under physiological conditions. These biocompatible polymers show potential for controlled drug release applications.

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    Area of Science:

    • Polymer Chemistry
    • Biomaterials Science
    • Drug Delivery Systems

    Background:

    • Poly(iminocarbonates) are a class of polymers with potential applications in biomedical fields.
    • Degradation under physiological conditions is a key property for biomaterials.
    • Controlled release of active agents is crucial for effective drug delivery.

    Purpose of the Study:

    • To synthesize and characterize poly(iminocarbonates) based on hydroquinone and Bisphenol A.
    • To investigate the degradation behavior of these polymers under physiological conditions.
    • To evaluate their potential for controlled release of active compounds and assess initial biocompatibility.

    Main Methods:

    • Synthesis of poly(iminocarbonates) using diphenols like hydroquinone and Bisphenol A.

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  • Degradation studies under physiological conditions.
  • Drug release studies using Eosin Y and p-nitroaniline.
  • Fabrication of polymer forms such as discs, films, and fibres.
  • Initial toxicological assessments including implantation in rabbit corneas and mouse subcutaneous tissues.

    • Main Results:

    • Poly(iminocarbonates) synthesized from hydroquinone and Bisphenol A degraded under physiological conditions.
    • Poly(hydroquinone-iminocarbonate) exhibited near zero-order release of Eosin Y at low loadings.
    • Poly(Bisphenol A-iminocarbonate) formed transparent films and strong fibers, demonstrating high tensile strength and toughness.
    • Poly(Bisphenol A-iminocarbonate) thin films showed complete erosion in approximately 200 days under physiological conditions.
    • Poly(Bisphenol A-iminocarbonate) films displayed a lag phase followed by near zero-order release of p-nitroaniline for 90 days.
    • Initial toxicological studies indicated no inflammatory response upon implantation.

    Conclusions:

    • Poly(iminocarbonates) based on hydroquinone and Bisphenol A are biodegradable under physiological conditions.
    • These polymers show promise for controlled drug delivery systems, with tunable release profiles.
    • Poly(Bisphenol A-iminocarbonate) possesses favorable mechanical properties and biocompatibility, suggesting its utility in various biomedical applications.