Functional connectivity from dorsolateral prefrontal cortex mediates the impact of social jetlag on depressive...

Social jetlag (SJL), a form of circadian rhythm disturbance, is linked to depressive symptoms; however, it is unclear what role the brain network, particularly the reward and cognitive control circuits, plays in this association. To address this issue, employing the ventral striatum (VS) and dorsolateral prefrontal cortex (DLPFC) as seeds, we used voxel-level whole-brain functional connectivity (FC) to determine the neural basis of the association between SJL and depressive tendency. Behavioral results indicated that SJL was positively associated with depression scores. Functional connection results showed that higher SJL was linked with decreased FC between the inferior orbitofrontal cortex and the VS. For DLPFC, we discovered changed FC in frontal, parietal, and occipital lobes related to SJL. More importantly, the mediation analysis revealed that the DLPFC-cuneus FC significantly mediated the relationship between SJL and depression scores. According to our study, higher SJL showed abnormal FC from the VS and DLPFC, which may involve attention impairments, cognitive control and reward function. Our results suggest that brain FC involving visual attention may explain the relationship between SJL and depressive tendency. This may offer new insights into the neural underpinnings of how circadian misalignment leads to mood issues.