Study on the Interaction between Silibinin and Neuraminidase
Haowen Fang1,2, Yanting Ding1,3,4, Yi Lu2
1School of Environmental and Chemical Engineering, Shanghai University, Shanghai, P.R. China.
Background:
Neuraminidase is a pathogenic protein of the avian influenza virus. Previous studies have shown that silibinin has the potential to inhibit neuraminidase activity.
Objective:
This study aims to explore the interaction between silibinin and neuraminidase and the effect of silibinin on the structure and activity of neuraminidase.
Methods:
In this study, two-dimensional fluorescence spectrum, three-dimensional fluorescence spectrometry, Uv-vis spectroscopy, and circular dichroism analysis were used.
Results:
Silibinin alters the secondary structure of neuraminidase and inhibits the activity of neuraminidase.
Conclusion:
Silibinin can interact with neuraminidase and inhibit its activity.
