Study on the Interaction between Silibinin and Neuraminidase
Haowen Fang1,2, Yanting Ding1,3,4, Yi Lu2
1School of Environmental and Chemical Engineering, Shanghai University, Shanghai, P.R. China.
Current Pharmaceutical Design
|May 16, 2023
Summary
Silibinin interacts with avian influenza neuraminidase, altering its structure and inhibiting its activity. This finding highlights silibinin
Area of Science:
- Biochemistry
- Virology
- Molecular Biology
Background:
- Neuraminidase is a key pathogenic protein of the avian influenza virus.
- Silibinin has demonstrated potential in inhibiting neuraminidase activity in prior research.
Purpose of the Study:
- To investigate the interaction between silibinin and avian influenza neuraminidase.
- To determine the effects of silibinin on neuraminidase structure and enzymatic activity.
Main Methods:
- Utilized two-dimensional fluorescence spectrum.
- Employed three-dimensional fluorescence spectrometry.
- Conducted UV-Vis spectroscopy and circular dichroism analysis.
Main Results:
- Silibinin was observed to alter the secondary structure of neuraminidase.
- Silibinin significantly inhibited the enzymatic activity of neuraminidase.
Conclusions:
- Silibinin effectively interacts with avian influenza neuraminidase.
- Silibinin demonstrates inhibitory effects on neuraminidase activity, suggesting therapeutic potential.
Keywords:
NeuraminidasePeramivirUv-vis spectroscopyavian influenza virusdrugsneuraminidase inhibitorsilibinin
