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Published on: June 2, 2014
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Increased serum prolactin level may indicate more migraine attack frequency
Mansoureh Togha1,2, Shiva Nematgorgani1, Zeinab Ghorbani3,4
1Headache Department, Iranian Centre of Neurological Research, Neuroscience Institute, Tehran University of Medical Sciences, Tehran, Iran.
Brain and Behavior
|May 16, 2023
Summary
Serum prolactin (PRL) levels were significantly higher in chronic migraine and during episodic migraine attacks compared to between attacks or in controls. Elevated PRL may be linked to migraine progression.
Area of Science:
- Neurology
- Endocrinology
Background:
- Migraine is a complex neurological disorder with unclear mechanisms.
- Previous studies show inconsistent findings regarding serum prolactin (PRL) levels in migraine patients.
Observation:
- This case-control study compared serum prolactin levels in chronic migraine (CM), episodic migraine (EM) during ictal and interictal phases, and headache-free controls.
- Blood samples were analyzed for serum prolactin concentrations (ng/mL).
Findings:
- Serum prolactin levels were significantly elevated in CM and ictal EM groups compared to interictal EM and control groups (p < .001).
- Interictal EM prolactin levels were higher than controls, but not significantly.
- A correlation was found between serum prolactin levels and headache frequency in migraineurs.
Implications:
- Increased prolactin concentrations may be associated with migraine induction and progression.
- Further research is needed to validate the role of serum prolactin in migraine pathogenesis.
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