Related Experiment Video

Updated: Jul 30, 2025

Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions
09:30

Mesenchymal Stem Cell Isolation from Pulp Tissue and Co-Culture with Cancer Cells to Study Their Interactions

Published on: January 7, 2019

10.4K

Mesenchymal stem cells- an excellent therapeutic agent for cancer

Anjilikal TomyTomcy1, Edakkadath Raghavan Sindhu2

  • 1Department of Human Genetics and Molecular Medicine, Central University of Punjab, Bathinda, India.

Asia-Pacific Journal of Clinical Oncology
|May 16, 2023
PubMed

Insights

Mesenchymal stem cells (MSCs) show promise in cancer therapy due to their tumor-targeting and immune-modulating abilities. This review explores their anticancer properties and the benefits of engineered MSCs for improved cancer treatment strategies.

Area of Science:

  • Oncology
  • Regenerative Medicine
  • Cell Therapy

Background:

  • Cancer remains a leading cause of death worldwide, with conventional therapies often leading to resistance and recurrence.
  • Cell therapies and regenerative medicine, particularly using stem cells, offer alternative treatment strategies.
  • Mesenchymal stem cells (MSCs) are a key focus in regenerative medicine due to their therapeutic potential.

Purpose of the Study:

  • To review the anticancer properties of mesenchymal stem cells (MSCs).
  • To examine the effects of MSCs on various cancer signaling pathways.
  • To discuss the advantages of engineered MSCs in cancer therapy.

Main Methods:

  • Literature review focusing on mesenchymal stem cells (MSCs) and their role in cancer.
  • Analysis of studies detailing MSCs' tumor-tropic and immune-modulatory functions.
  • Examination of research on engineered MSCs for enhanced therapeutic efficacy.

Main Results:

  • MSCs possess inherent tumor-homing and immune-regulatory capabilities beneficial for cancer treatment.
  • MSCs influence multiple signaling pathways relevant to cancer progression and suppression.
  • Engineered MSCs demonstrate enhanced potential compared to non-engineered counterparts in preclinical cancer models.

Conclusions:

  • Mesenchymal stem cells (MSCs) represent a promising cell-based therapy for cancer.
  • Targeting signaling pathways with MSCs offers a novel approach to combatting cancer.
  • Further development of engineered MSCs could significantly advance cancer treatment options.
Keywords:
antitumor activityexosomesmesenchymal stem cellsnanoparticlessignaling pathways

More Related Videos

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples08:58

An Enzymatic Method to Rescue Mesenchymal Stem Cells from Clotted Bone Marrow Samples

Published on: April 12, 2015

9.3K
A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells11:15

A Preclinical Mouse Model of Osteosarcoma to Define the Extracellular Vesicle-mediated Communication Between Tumor and Mesenchymal Stem Cells

Published on: May 6, 2018

10.3K

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.8K
Stem Cell Therapy for Tissue Regeneration01:21

Stem Cell Therapy for Tissue Regeneration

Stem cell therapy is a method used in regenerative medicine to repair and restore function to damaged tissues and organs. Stem cells have the potential to proliferate and differentiate into various tissue types, making them ideal candidates for tissue regeneration. For example, hematopoietic stem cell transplants are commonly used in blood cancer treatment to replenish damaged bone marrow and restore healthy blood cells.
Types of Stem Cells used in Stem Cell Therapy
The two main cell...
4.1K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
5.0K
Stem Cell Culture01:17

Stem Cell Culture

Stem cell research aims to find ways to use stem cells to regenerate and repair cellular damage. Over time, most adult cells undergo the wear and tear of aging and lose their ability to divide and repair themselves. Stem cells do not display a particular morphology or function. Adult stem cells, which exist as a small subset of cells in most tissues, keep dividing and can differentiate into a number of specialized cells generally formed by that tissue. These cells enable the body to renew and...
5.3K
iPS Cell Differentiation01:22

iPS Cell Differentiation

The ability of induced pluripotent stem cells or iPSCs to differentiate into most body cell types has stimulated repair and regenerative medicine research over the past few decades. iPSC-derived blood cells, hepatocytes, beta islet cells, cardiomyocytes, neurons, and other cell types can repair injuries or regenerate damaged tissue in diseases such as diabetes and neurodegenerative disorders.
2.8K