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Published on: May 6, 2019
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Insights into phenotypic and functional CD8+ TRM heterogeneity
Maximilian Heeg1, Ananda W Goldrath1
1Department of Molecular Biology, School of Biological Sciences, University of California San Diego, La Jolla, California, USA.
Immunological Reviews
|May 16, 2023
Summary
Tissue-resident memory T cells (TRM) are crucial for rapid immune defense. Recent single-cell studies reveal significant heterogeneity within these CD8+ T cells, impacting their function and longevity.
Area of Science:
- Immunology
- Cell Biology
- Molecular Biology
Background:
- Cytotoxic CD8+ T cells eliminate infected or cancerous cells.
- Tissue-resident memory T cells (TRM) provide rapid, localized immune surveillance in peripheral tissues.
- TRM cells are transcriptionally and epigenetically distinct, adapting to their tissue environment for long-term survival.
Purpose of the Study:
- To review and discuss recent findings on CD8+ TRM heterogeneity.
- To explore the implications of TRM heterogeneity for immune protection.
- To consider the impact of TRM heterogeneity on the design of immune therapies.
Main Methods:
- Single-cell molecular profiling techniques.
- Analysis of transcriptional and epigenetic data.
- Comparative studies across different tissues and infection models.
Main Results:
- Significant heterogeneity exists within CD8+ TRM populations across various tissues.
- Specialized TRM subsets have been identified within individual tissues.
- This heterogeneity is dependent on time and infection history.
Conclusions:
- TRM cell heterogeneity influences their function and persistence.
- Understanding TRM heterogeneity is key for enhancing immune responses.
- Insights into TRM heterogeneity can guide the development of novel immunotherapies.
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