Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Bone-marrow plasmocytosis--an immunohistological study.

F Eckert, L Schmid, D Kradolfer

    Blut
    |July 1, 1986
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Renal cortical T1 times at 1.5 T: exploratory reference estimates from a real-world cohort with preserved renal function.

    European journal of radiology open·2026
    Same author

    Application of artificial intelligence on magnetocardiology.

    Clinical hemorheology and microcirculation·2026
    Same author

    Radiobiology and modelling in Brachytherapy: A review inspired by the ESTRO Brachytherapy pre-meeting course.

    Clinical and translational radiation oncology·2024
    Same author

    Supplementary orthopaedic screening for children and adolescents to prevent permanent skeletal deformities - protocol for the "OrthoKids" study.

    BMC musculoskeletal disorders·2023
    Same author

    Single chest drain is not inferior to double chest drain after robotic esophagectomy: a propensity score-matched analysis.

    Frontiers in surgery·2023
    Same author

    Integration of radiation oncology teaching in medical studies by German medical faculties due to the new licensing regulations : An overview and recommendations of the consortium academic radiation oncology of the German Society for Radiation Oncology (DEGRO).

    Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al]·2021

    The immunoperoxidase method helps distinguish multiple myeloma from reactive plasmocytosis and monoclonal gammopathy of undetermined significance (MGUS) by analyzing kappa/lambda ratios in bone marrow. Differentiation between MGUS and reactive plasmocytosis remains challenging.

    Area of Science:

    • Hematology
    • Immunohistochemistry
    • Oncology

    Background:

    • Plasmacytic disorders, including multiple myeloma and monoclonal gammopathy of undetermined significance (MGUS), are characterized by abnormal plasma cell proliferation.
    • Accurate differentiation of these conditions is crucial for appropriate patient management and prognosis.

    Purpose of the Study:

    • To evaluate the utility of the immunoperoxidase method in characterizing plasmacytic disorders.
    • To assess the diagnostic value of kappa/lambda light chain ratios in distinguishing multiple myeloma from MGUS and reactive plasmocytosis.

    Main Methods:

    • Bone marrow biopsies and smears from 59 patients were analyzed.
    • The immunoperoxidase method was employed to quantify cytoplasmic immunoglobulin and determine kappa/lambda ratios.

    Related Experiment Videos

  • Patients included those with reactive plasmocytosis, multiple myeloma, solitary plasmocytoma, and MGUS.

    • Main Results:

    • Distinct kappa/lambda ratio ranges were observed for multiple myeloma (≤0.1 and ≥11.2), reactive plasmocytosis (0.4-3.5), and MGUS (0.2-3.0).
    • The immunoperoxidase method effectively differentiated overt multiple myeloma from MGUS and reactive plasmocytosis.
    • Histological and immunohistological methods could not reliably distinguish between MGUS and reactive plasmocytosis.

    Conclusions:

    • The immunoperoxidase method, by analyzing kappa/lambda ratios, is a valuable tool for characterizing plasmacytic disorders.
    • This technique aids in distinguishing multiple myeloma from other plasmacytic conditions.
    • Further investigation may be needed to improve the differentiation between MGUS and reactive plasmocytosis.